Police are investigating a serious crash involving a pedestrian at Moonah overnight.

Police responded to the incident in Charles Street just before 1am after a woman was struck by a vehicle and seriously injured.

The vehicle had left the scene prior to police arrival.

The woman was taken to the Royal Hobart Hospital where she remains in a serious, but stable condition.

Investigations into the crash are ongoing, and police are calling for any witnesses or dash cam footage from the Charles Street, Moonah area shortly before 1am Monday 2 February.

Information can be provided by calling police on 131 444 or Crime Stoppers anonymously on 1800 333 000 or online at crimestopperstas.com.au.