Police are calling for information from members of the public who may have witnessed a serious motor vehicles crash that occurred at 1:12am on Friday morning in Bounty Street, Warrane.

A 25 year old woman was driving a white Holden station when she drove at speed into the front yard of a house in Bounty Street striking a 29 year old man. The woman and man are known to each other.

The man was taken by ambulance to the Royal Hobart Hospital in a serious condition.

The woman is in custody as investigations into the cause of the crash continue.

Anyone with information is asked to contact police on 131 444 or Crime Stoppers on 1800 333 000 or at crimestopperstas.com.au. Information can be provided anonymously.