Police are investigating a serious crash involving a yellow Triumph motorcycle and a white Isuzu truck this morning.

Police and emergency services were called to the scene on the Huon Highway, near Sandfly about 8:15am

Preliminary investigations indicate the motorcycle collided with the rear of the truck.

The 22-year-old man riding the motorcycle was taken to hospital with what are believed to be serious injuries.

The 40-year-old man driving the truck was not physically injured.

The right-hand lane of the highway was closed for 3 hours to allow crash investigators to examine the scene and conduct inquiries. Police would like to thank motorists for their patience and understanding.

Anyone with information or relevant dashcam footage relating to the crash is asked to contact police on 131 444 or Crime Stoppers on 1800 333 000 or at crimestopperstas.com.au. Information can be provided anonymously.